Abstract 5620: Radiogenomic analysis in the patients with primary brain tumor using dual time point 18F-FET PET/CT

Abstract

Listen

Translate article

Abstract Purpose: To evaluate the association between genomic data and imaging features of dual time point 18F-FET PET/CT in patients with primary brain tumor for radiogenomic mapping. Methods: From June 2021 to July 2022, we prospectively enrolled the patients under suspicious of de novo primary brain tumor in Asan Medical Center. Prior to the surgery, contrast-enhanced MRI and 18F-FET PET/CT scans were routinely performed. Twenty minutes after the post-injecting (p.i.) approximately 5 mCi of 18F-FET, patients underwent early PET/CT acquisition (20-40 min p.i.). Delay PET/CT (80-100 min p.i) was subsequently obtained after 40-minute break. SUVmax, maximum tumor-to-brain ratios and PET-positive volumes using different isocontours of SUVmax (I30, I60, I90%) in tumor were calculated in each sum images. Histopathologic results were made based on 2016 WHO classification and, isocitrate dehydrogenase (IDH) mutation, O6-methylguanine-DNA methyltransferase (MGMT) methylation, telomerase reverse transcriptase (TERT) mutation and co-deletion of 1p19q status were investigated as well. Spearman’s correlation coefficient (r), logistic regression and AUC-ROC analysis were employed using aforementioned radiomics information. Results: A total of 42 patients (median age 55.5 yrs, range 21-84; M:F=31:11) were recruited and, 29 patients had glioblastoma with grade IV. Except TERT mutation (n=25), IDH mutation (n=11), MGMT methylation (n=19) and co-deletion of 1p19q (n=8) had statistically significant correlation each other (IDH vs. MGMT, r=0.55; IDH vs. 1p19q, r=0.53; MGMT vs. 1p19q, r=0.42). Early scan of I60% was closely related with IDH mutation (positive, 3.92 ± 3.04 vs. negative, 7.96 ± 5.36; p=0.005) meanwhile delay scan of I30% had significant association with co-deletion of 1p19q (present, 34.16 ± 18.67 vs. absent, 71.99 ± 38.79; p=0.01). The accuracy of logistic regression and the corresponding AUC-ROC values for IDH/MGMT/TERT/co-deletion of 1p19q status were 0.86/0.73/0.78/0.85, and 0.88/0.76/0.78/0.91, respectively. Conclusion: Although this is a preliminary and interim analysis during our prospective study being slated to enroll the patients until December 2023, we suggest that the information acquired from both genetics and 18F-FET could be integrated into better characterization of primary brain tumor. Citation Format: Dong Yun Lee, Sang Woo Song, Seungjoo Lee, Minyoung Oh, Jungsu S. Oh, Jaeseung Kim. Radiogenomic analysis in the patients with primary brain tumor using dual time point 18F-FET PET/CT. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5620.