Abstract 5601: Statin-Use and Increase of Adiponectin Enhance the Stabilization and Regression of Coronary Arterial Plaques Characterized by Low- and High-Density Lipoprotein Cholesterols

Abstract

Low levels of low-density lipoprotein cholesterol (LDL-C) or promotion of the biologic activity of high-density lipoprotein cholesterol (HDL-C) have a dramatic impact on atheroma burden. We assessed the hypothesis that lipoprotein cholesterol levels played major roles in the development of coronary plaque characterization. Preintervention intravascular ultrasound-Virtual Histology (IVUS-VH), using a continuous pullback (0.5 mm/s) was performed prospectively in 92 coronary vessels in consecutive 92 patients with coronary artery disease. The morphological distribution of plaque was evaluated up to a total length of 60 mm per coronary vessel. The levels of LDL-C were positively correlated with % necrotic core (NC) tissue (r=0.31, P=0.003). Whereas, HDL-C levels were negatively correlated with plaque volume (r=−0.30, P=0.003). These relations were closely observed in patients with acute coronary syndrome (ACS) compared with those with stable angina pectoris. Based on a receiver operating characteristic curve, the best cutoff LDL-C levels on % NC tissue and HDL-C levels on plaque volume were plotted regarding ACS patients (Figure ). In multiple regression analyses, % NC tissue and plaque volume were associated with statin-use and adiponectin levels, respectively (Table ). IVUS-VH may help to explain missing link between lipids and coronary plaque characterization. Statin-use and increase of adiponectin have a huge potential for stabilization and regression of coronary arterial plaques. The levels of LDL-C ≤ 70 mg/dL and HDL-C ≥60 mg/dL are recommended and may contribute to the development of preventive strategies of ACS.