Abstract 5566: Serum Tenascin-C Levels Might be a Novel Biomarker for Predicting Short-term Prognosis of Type B Acute Aortic Dissection

Abstract

Backgrounds: Tenascin-C (TN-C), an extracellular matrix glycoprotein, is not normally expressed in adult heart and aorta, but transiently reappears under various pathologic conditions playing important roles in tissue remodeling. The aim of this study is to clarify the clinical implication of serum TN-C levels in patients with type B acute aortic dissection (AD). Methods: We evaluated 43 patients with type B acute AD between May 2005 and January 2008 and 20 normal controls. We measured serum TN-C levels by ELISA on admission, 7 days, 14 days and 28 days after admission. We compared serum TN-C levels with blood biomarkers, and short-term clinical outcome at a discharge. Results: Serum TN-C levels (66.4 ng/ml) in AD was significantly higher than normal controls (27.4 ng/ml) at admission (p<0.01). Serum TN-C levels in AD significantly increased at 7 days (82.4 ng/ml), and then gradually decreased to normal range at 28 days (40.4 ng/ml). Serum TN-C levels at 7 days was positively correlated with peak C-reactive protein levels (R=0.45, p=0.02). Three patients of AD died. Serum TN-C levels at 7 days of the death group were significantly higher than those of survival group (79.8±51.5 vs. 168.6±98.6 ng/ml, p=0.01). Conclusions: We demonstrated that serum TN-C levels are significantly elevated during acute stage after AD, and might be a novel biomarker for prediction of patient prognosis with type B acute AD.