Abstract
Abstract The A subunit of Shiga-like Toxin 1 (SLT1) is a ribosome-inactivating protein that works by catalyzing the depurination of the 28 S rRNA. The A subunit lacks the ability to bind and internalize into cells, and is normally dependent on the B subunit of SLT1 for this function. A toxin variant library has been created by inserting random amino acid stretches into an exposed loop structure of the A subunit. The inserts can confer binding and internalization properties to the SLT1 A variants but do not inhibit the A subunit's ability to intoxicate. This toxin library has been expressed in a phage display system that can be rapidly screened for variants with specific cell kill activity and predictable PK/PD properties. The library is being used to develop novel therapeutics for oncology. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5506.
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