Abstract

Background: Patients with Renal Artery Stenosis (RAS) who fail medical management may be evaluated for Percutaneous Transluminal Renal Artery Angioplasty (PTRA). Comorbidities increasing the risk of complications following PTRA have not been explored well. Methods: Patients undergoing PTRA for RAS were sampled using National Inpatient Sample (NIS) Database. Demographics, length of stay (LOS), and comorbidities were gathered using ICD-10 codes. Complications included heart failure, myocardial infarction, cardiac arrest, major bleeding, stent thrombosis, renal artery dissection/embolism, aortic dissection/rupture and atheroembolism. Extended LOS (ELOS) was defined as LOS greater than 4 days. Univariate and multivariate logistic regression analyses were used to identify predictors for complications and ELOS. Results: 517 patients underwent PTRA. Most prevalent comorbidities were peripheral vascular disease, coronary artery disease and dyslipidemia. On multivariate analysis, comorbidities significant for predicting major complications were end-stage renal disease, chronic liver disease, heart failure and coagulable disorders whereas comorbidities significant for predicting ELOS were chronic lung disease, chronic liver disease, diabetes and coagulable disorders (Figure 1). Conclusion: As we continue to identify the ideal candidates for PTRA, it is important to consider the comorbidities that predispose these patients to increased periprocedural complications and ELOS.

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