Abstract 542: Race, Sex, And Age Differences In Peripheral Arterial Disease-related Mortality In The United States, 2000 To 2019

Abstract

Introduction: Peripheral arterial disease (PAD) is a progressive atherosclerotic disease associated with significant morbidity and mortality in the US, however, data regarding mortality trends is limited. This study uses national death certificate data to characterize contemporary trends in PAD-related mortality in the US. Methods: The Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research (CDC WONDER) was queried for data regarding PAD-related deaths from 2000 to 2019 in the overall sample and from different demographics (age, sex, race). Crude and age-adjusted mortality rates (AAMR) per 100,000 people were calculated. Associated average percentage changes (APC) were computed using Joinpoint trend analysis software. Results: Between 2000 and 2019, a total of 1,959,050 PAD-related deaths occurred in the study population. Overall, AAMR decreased from 2000 to 2016, but remained relatively the same between 2016 to 2019. Men, Non-Hispanic (NH) Black or African American, NH American Indian or Alaska Native, and NH Asian or Pacific Islander showed a decline in AAMR. Women, NH White, Hispanic or Latino, ages 55 to 69 years, and 70 to 84 years showed initial declines, with no change in recent years. Ages 40 to 54 only had a change in crude mortality between 2002 and 2010. Overall, men, NH Black or African American individuals, and people aged 85+ were associated with the highest AAMRs of their respective subgroups throughout the study period. Notably, there was an increase in crude mortality rate amongst individuals 25-39 years of age from 2009 to 2019. Conclusion: PAD-related mortality in the US decreased from 2000 to 2016 but has stabilized in recent years. Despite improvement, disparities amongst sex, race, and age remain. Figure 1. PAD-related mortality rates by 1.A. sex 1.B. race 1.C. ages 25-54 and 1.D. ages 55-85+ in the United States, 2000 to 2019. *Indicates that APC is significantly different from zero at α=0.05.