Abstract
Abstract The receptor for advanced glycation end-products (RAGE) is a newly recognized factor regulating cancer cell invasion and metastasis. RAGE has recently been recognized as a cancer-associated protein responsible for cancer progression and metastasis in gastrointestinal and epithelial cancers. The aim was to examine the role of RAGE in breast cancer previous to chemotherapy treatment. Methods: A retrospective study in surgical specimens obtained from 68 consecutive patients who underwent surgery for stage II-III breast cancer at the Oncology Hospital at National Medical Center SXXI, between 2008 and 2009. RAGE expression was examined by immunohistochemistry (IHQ) and PCR in 68 patients with stage II or III breast cancer previous chemotherapy treatment. RAGE expression was compared with clinicopathological parameters including clinical stage, invasive depth, nodal metastasis, disease recurrence and disease-free survival. The positive expression rate of RAGE was defined as 50% or more of stain in IHQ. Results: In all 68 samples no RAGE membrane expression was found significantly. Just one specimen was 50% positive in tumor IHQ and no clinicopathological correlation was found. In PCR the results were more significant. Our findings shows suggestive no evidence for the presence of RAGE in membrane, but possibly RAGE gene expression could had relationship in the progression of breast cancer in stages II and III. Citation Format: Jorge A. Guadarrama-Orozco, Erika B. Ruiz-García, Hector A. Maldonado-Martinez, Lilia P. Barron-Rodríguez, Fernando Mainero-Ratchelous, Horacio Astudillo-delaVega. Determination of the receptor for advanced glycation end-products in breast cancer patients previous chemotherapy. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5292. doi:10.1158/1538-7445.AM2015-5292
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