Abstract
Objective: To investigate the regulation of Nogo/ROCK- norepinephrine transporter (NET) signaling pathway on myocardial hypertrophy and fibrosis in spontaneously hypertensive rats (SHR). Methods: Twenty male SHR rats aged 7-week-old were randomly divided into four groups: control group (n=5), NEP1-40 group (n=5), fasudil group (n=5) and fluoxetine group (n=5), and fed for 7 weeks. Left ventricular mass (LVW) was separated and weighed. Left ventricular mass index (LVMI) was calculated. Real-time quantitative PCR was used to detect the gene expression of myocardial hypertrophy and fibrosis and NET. Results: Compared with the control group, the left ventricular mass index (LVMI), the gene expression of ANP, BNP andβ-MHC were significantly increased in NEP1-40 group, and were significantly decreased in Fasudil group. Compared with the control group, the gene expression of CTGF, Collagen I and Collagen III increased significantly in NEP1-40 group, while decreased significantly in Fasudil group. Compared with the control group, the gene expression of norepinephrine transporter (NET) significantly increased in fasudil group. Compared with the control group, the gene expression of ANP, BNP, β-MHC, CTGF and Collagen I were significantly increased in fluoxetine group. Conclusion: Nogo/ROCK-NET signaling pathway is involved in the regulation of myocardial hypertrophy and fibrosis in spontaneously hypertensive rats.
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