Abstract 5138: Development of a gold nanoparticle platform capable of selective homing to tumor tissues for intravenous antitumor therapy

Abstract

Abstract Intratumoral administration of high mobility group nucleosome-binding protein 1 (HMGN1) and R848/resiquimod together with a checkpoint inhibitor can eradicate large established tumors. However, the intratumoral route of administration is difficult to use on cancers of internal organs. To improve potential clinical use of HMGN1 and R848, it is necessary to deliver HMGN1 and R848 systemically to the tumor tissue. Gold nanoparticles (AuNP) have been extensively studied as a vehicle for various types of drugs, including anticancer compounds. In this study, we established a means of generating PEGylated Au-HMGN1-R848 (Au-PEG-HMGN1-R848) complexes, which, upon intravenous IV administration, preferentially target ectopic hepatoma or colon tumor tissue and avoids uptake of the particles by liver and spleen of tumor-bearing mice. Additionally, Au-PEG-HMGN1-R848 complexes were stable and preserved the capacity of HMGN1 and R848 to stimulate the maturation of dendritic cells. IV administration of Au-PEG-HMGN1-R848 complexes plus a checkpoint inhibitor had effective antitumor activity in curing 80% of C57BL/6 mice bearing large (1 cm in diameter) Hepa1-6 hepatoma and Balb/c mice bearing CT26 colon tumors. Therefore, an Au nanoparticle platform capable of selectively delivering HMGN1 and R848 systemically to tumor tissues can be used to effectively to cure ectopic Hepa1-6 hepatoma and CT26 colon carcinoma. Note: This abstract was not presented at the meeting. Citation Format: Zhen Han. Development of a gold nanoparticle platform capable of selective homing to tumor tissues for intravenous antitumor therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5138. doi:10.1158/1538-7445.AM2017-5138