Abstract
Abstract Systemic sclerosis (SSc) is recognized as an autoimmune disorder characterized by immune dysregulation, obliterative vasculopathy, excessive accumulation of extracellular matrix, and fibrosis of the skin and other organs. It also ranks on the highest position of disease-related mortality and morbidity with an impaired quality of life among the rheumatologic illnesses. However, the immunological mechanism related to SSc remains to be elucidated systemically, which may lay for the novel therapeutic methodology. In the present study, we combined the MSD methodology and flow cytometry to landscape the chemokine or cytokine network, immunology response and signaling axis in mice on Blomycin induced SSc model. Our results provide the reference and path for the future direction of novel therapeutic reagents discovery. Citation Format: Yanping Yuan, Cheng Qian, Chuanzhi Yangmeng, Li Fang, Ruiqing Yan. Multi-plex cytokine profiling for mice on Bleomycin induced systemic sclerosis model. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5130.
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