Abstract
Objective: Saccharina japonica (SJ), one of brown algae, is cultivated or grows wild in Japan and neighbor countries. The extract “dashi” is used for soup stock in Japan. We reported the decreases in blood pressure (BP) both by the intake of SJ diet and by dashi extracted from SJ (DASHI) in 2-kidney, 1-clip renovascular hypertensive (2K1C) rats. Some researchers have suggested that alginic acid (AA) may be involved in the mechanism of the SJ effect. However, DASHI contains AA as much as 5%(5 of 100) of what the original SJ contains. Thus, the antihypertensive effects by SJ in 2K1C may be through the other contents of SJ. SJ is rich in Glutamic acid (GA) which is one of the umami, the intake of which was reported to decrease BP in human in epidemiologic studies. GA is eluted from the SJ into the DASHI when extracting DASHI from SJ. Therefore, we hypothesized that GA in DASHI contributes to the mechanism of BP decreased by DASHI diet in 2K1C rats. In this study, we observed BP in 2K1C rats fed a diet containing GA as much as that in the SJ diet which had decreased BP in the previous study. Methods: Male Sprague-Dawley rats (6wks) were treated with sham operation (SHAM) or clipping the left renal artery (2K1C). After surgery, the rats started receiving a control diet (C) or a diet containing L-GA (G) for 6 weeks. The systolic BP (SBP) was measured by a tail-cuff method every week. At the end, mean arterial BP (MAP) was measured in each rat under anesthesia. Result: Six weeks after the surgery, SBP was significantly higher in 2K1C-C than in SHAM-C (163±2 vs 111±5 mmHg, p<0.05). In 2K1C-G (171±7), it showed no significant difference compared with 2K1C-C and was significantly higher than that in SHAM-C (p<0.05). At the end of the protocol, MAP showed the similar results to SBP. Conclusion: Glutamic acid may not contribute to the mechanism of alleviating hypertension by dietary SJ and SJ extract in 2K1C.
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