Abstract

Background: Fatty acid binding protein-4 (FABP4) is a lipid chaperon that carries fatty acids and other lipophilic substances to specific compartments in the cell. It is mostly expressed in macrophages and adipocytes and is associated with insulin resistance, obesity and atherosclerosis. Previous studies have shown the role of FABP4 in high risk phenotypes of atherosclerotic plaques featuring inflammation and vulnerability of the plaques in cardiovascular diseases. Hence we hypothesis that FABP4 is produced by macrophages in the human coronary atherosclerosis and might be involved in aggravation of the disease. Materials and methods: Human coronary arteries which were formalin fixed and paraffin embedded were used with IRB review. Immunohistochemistry was performed on these samples to analyze the expression of FABP4 and co-localization of CD68 (macrophage marker) in the atherosclerotic plaques of these human coronary arteries. Results: Atherosclerotic plaques in the human coronary arteries expressed both FABP4 and CD68. Conclusion: Macrophages in the plaques of human plaques secrete FABP4 which is evident from the co-existence of both molecules in the atherosclerotic coronary arteries.

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