Abstract 4882: Factor V Leiden, But Not Prothrombin G20120A, Is Associated With Premature Myocardial Infarction

Abstract

HomeCirculationVol. 118, No. suppl_18Abstract 4882: Factor V Leiden, But Not Prothrombin G20120A, Is Associated With Premature Myocardial Infarction Free AccessMeeting ReportAboutSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessMeeting ReportClinical ScienceHuman Genetics of Cardiovascular Disease and TherapyAbstract 4882: Factor V Leiden, But Not Prothrombin G20120A, Is Associated With Premature Myocardial Infarction Marta Spreafico, Flora Peyvandi, Luisa Foco, Luisa Bernardinelli, Stefano Duga, Rosanna Asselta, Diego Ardissino, Sekar Kathiresan, Piera A Merlini and Pier M Mannucci Marta SpreaficoMarta Spreafico Search for more papers by this author , Flora PeyvandiFlora Peyvandi Search for more papers by this author , Luisa FocoLuisa Foco Search for more papers by this author , Luisa BernardinelliLuisa Bernardinelli Search for more papers by this author , Stefano DugaStefano Duga Search for more papers by this author , Rosanna AsseltaRosanna Asselta Search for more papers by this author , Diego ArdissinoDiego Ardissino Search for more papers by this author , Sekar KathiresanSekar Kathiresan Search for more papers by this author , Piera A MerliniPiera A Merlini Search for more papers by this author and Pier M MannucciPier M Mannucci Search for more papers by this author Originally published28 Oct 2008https://doi.org/10.1161/circ.118.suppl_18.S_956-aCirculation. 2008;118:S_956AbstractBackground. Gain-of-function polymorphisms of genes encoding coagulation factor V (F5 G1691A) and prothrombin (F2 G20210A) increase circulating thrombin and are established risk factors for venous thrombosis. In atherothrombotic diseases, several studies yielded inconclusive results, mainly because sample sizes were too small owing to the low frequency of variant alleles. A meta-analysis of 66,155 cases and 91,307 controls (Lancet2006; 367:651Google Scholar) found that either polymorphism was associated with a moderately increased risk of coronary artery disease (CAD). Results from this meta-analysis, large but based upon 100 different studies all of rather small size, should be taken cautiously. Considering that genetic factors play a particularly important role in CAD occurring in the young, we chose to replicate the meta-analysis results by investigating an adequately large population of Italian patients who had developed myocardial infarction (MI) before the age of 45 yrs.Matherials and methods. Genotyping was performed by Sequenom MassARRAY platform. Statistical analysis was performed fitting a conditional logistic model with STATA 9.2 software.Results. In 1864 patients with MI (1655 men and 209 women) and 1864 age- and sex-matched controls, the minor A allele of F5 G1691A (2.6% frequency in cases and 1.7% in controls) was associated with a moderately increased risk of MI (OR:1.59;95% CI:1.14 –2.20; P=0.006). The association remained statistically significant after adjustment for traditional risk factors, including diabetes, smoking, hypertension and hypercholesterolemia (OR:1.81;95% CI:1.14 –2.87; P=0.012). The minor A allele of F2 G20210A, (2.4% frequency in cases and 1.9% in controls) was not associated with the risk of MI (OR:1.27;95% CI:0.93–1.74; P=0.133), even after adjustment (OR:1.19;95% CI:0.77–1.85; P=0.429).Conclusions. In this cohort of young MI patients, the largest investigated so far, the gain-of-function variant F5 G1691A (but not F2 G20210A) was associated with an increased risk of MI. Results of the previous meta-analysis are replicated only partially. Our results suggest that patients with of the FV gene variant, who carry a procoagulant phenotype, anticoagulant drugs might be considered for secondary prophylaxis of MI. Previous Back to top Next FiguresReferencesRelatedDetailsCited By Lotta L (2010) Genome-wide association studies in atherothrombosis, European Journal of Internal Medicine, 10.1016/j.ejim.2009.11.003, 21:2, (74-78), Online publication date: 1-Apr-2010. October 28, 2008Vol 118, Issue suppl_18 Advertisement Article InformationMetrics https://doi.org/10.1161/circ.118.suppl_18.S_956-a Originally publishedOctober 28, 2008 Advertisement