Abstract 4818: Type 2 diabetes mellitus and colorectal neoplasia risk in Puerto Rican Hispanics: A case-control study.

Abstract

Abstract Introduction: Epidemiological studies have provided inconclusive evidence regarding the potential link between type 2 diabetes mellitus (DM) and colorectal cancer (CRC).The association between type 2 DM and colorectal neoplasia (colorectal cancer and/or adenomas) has not been well studied in Hispanics, an ethnic minority at high risk for type 2 DM.The specific aim of the study was to evaluate the association between type 2 DM and colorectal neoplasia (CRN) in Puerto Rican Hispanic adults enrolled in the studies Epidemiology of Loss of Imprinting in Colorectal Cancer, Familial Colorectal Cancer Registry and the Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics: A case-control study at the VA Caribbean Healthcare System. Methods: The case-control study included patients with incident CRN and controls with negative colonoscopy and without previous history of CRC or adenomas diagnosed from January 1, 2005 to December 31, 2009. Diagnosis of type 2 DM was established by previous medical diagnosis and/or anti-diabetic medications use. Unconditional logistic regression was employed to estimate the odds ratio (OR) between type 2 DM and CRN using STATA 10.0. Results: A total of 501 participants (mean age 60.3 ± 12.6 yrs., 57.9% males), prevalence of type 2 DM was 24.8%. 323 patients with CRN and 178 controls were evaluated. In the cases, the prevalence of colorectal adenomas was 25.7% (83/323) and the prevalence of colorectal cancer was 74.3% (240/323). Cases and controls did not differ by gender (p=0.19), median age (p=0.91), family history of CRC (p=0.76) and first degree of family history of DM (p=0.49). Cases had lower education (p<0.001) and reported lower use of NSAIDS (p=0.054) and physical activity (p=0.005) compared to the controls. There were no statistical significant associations between DM and CRN (OR=1.21; 95% CI: 0.79-1.87), DM and CRC (OR=1.20; 95% CI: 0.76-1.90) or DM and colorectal adenomas (OR=1.24; 95% CI: 0.68-2.27). Conclusions: We did not observe a statistical significant association between type 2 DM and CRN. Nonetheless, a tendency towards an increase risk of colorectal neoplasia was observed among type 2 DM patients. Possible explanation for our lack of association may be related to high prevalence of type 2 DM in cases and controls. Citation Format: Yaritza Diaz-Algorri, Dilka Gonzalez, Maria E. Lozada, Sofia Margarita Lopez-Diaz, Jessica Hernandez, Carmen Pedrosa, Doris Toro, Marcia R. Criuz-Correa. Type 2 diabetes mellitus and colorectal neoplasia risk in Puerto Rican Hispanics: A case-control study. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4818. doi:10.1158/1538-7445.AM2013-4818