Abstract 4693: Maternal GSTP1 Ile105Val polymorphism and petrochemical exposure in relation to the childhood leukemia in southern Taiwan

Abstract

Abstract We conducted a population-based case-control study in an industrial city of southern Taiwan to investigate childhood leukemia risk in relation to the association of maternal and offspring polymorphisms with residential petrochemical exposures. A total of 109 leukemia cases and 220 controls younger than 20 years were recruited between November 1997 and December 2005. A procedure using geographic information system tools was used to estimate individual-level exposure by accounting for subjects’ mobility, length of stay at each residence, distance to petrochemical plant(s), and monthly prevailing wind direction. Multivariate logistic regression was used to assess the effects of petrochemical exposures, maternal and offspring's GSTP1 genotypes, and their joint roles on offspring's leukemia risk. No main effect of residential petrochemical exposure was observed, yet the exposure association was influenced by maternal GSTP1 genotypes alone as well as by the combined maternal and offspring genotypes (P for interaction=0.02 and 0.01, respectively). Among the subjects with both mothers and offspring carrying the GSTP1 105Val variant allele(s), the adjusted odds ratio was 1.34 (95 percent confidence interval: 1.02, 1.76) for each unit of increase in the log-transformed exposure opportunity score. In conclusion, this study suggests that the childhood leukemia risk is associated with the residential petrochemical exposures, modified by both offspring's and maternal GSTP1 genotypes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4693.