Year-end Sale % OFF 
Abstract
Abstract Background Recent trials demonstrated that the adjuvant chemotherapy for stage II or III gastric cancer after curative D2 gastrectomy is effective for preventing recurrence. The objective of this study was to clarify the risk factors for recurrence in patients who received adjuvant chemotherapy after curative D2 gastrectomy. Materials and methods We retrospectively analyzed the factors predicting recurrence in 206 patients with stage II or III gastric cancer who received oral S-1 or 5-FU and cisplatin (FP) chemotherapy following curative D2 gastrectomy between April 2004 and December 2011. Results The median follow-up time after surgery was 2.93 years. A total of 136 patients received FP chemotherapy, and 70 patients received S-1. 3 year recurrence-free survival was 66.7%. In univariate analysis, gastroesophageal junction cancer, stage III, T3/T4 tumor, N2/N3 nodal status, and presence of both lymphovascular invasion (LVI) and perineural invasion (PNI) were associated with shorter recurrence-free survival. Moreover, Multivariate analysis showed male (HR 1.909; 95% CI 1.067-3.417; p=0.029), stage III (HR 3.884; 95% CI 1.741-8.662; p=0.001), and presence of both LVI and PNI (HR 2.293; 95% CI 1.367-3.846; p=0.002) were independent risk factors for recurrence. Conclusion Presence of both LVI and PNI is a strong recurrence risk factor for patients with stage II and stage III R0 resected gastric cancer who received adjuvant chemotherapy. Citation Format: Jun-Eul Hwang, Min-Jee Kim, Hyun-Jeong Shim, Woo-Kyun Bae, Sang-Hee Cho, Ik-Joo Chung. Recurrence risk factors for advanced gastric cancer after D2 gastrectomy followed by adjuvant chemotherapy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4682. doi:10.1158/1538-7445.AM2014-4682
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
