Abstract
Abstract Kaplan et al (Nature 438, 820-827, 2005) demonstrated that bone marrow cells can home to tumor-specific pre-metastatic sites thereby providing a permissive niche for incoming metastatic cells. In the present study, bone marrow cells, which were harvested from tumor-bearing mice, were able to form a strong niche compared to bone marrow cells which were harvested from non-tumor-bearing mouse upon co-implantation with cancer cells. When GFP-bone marrow cells from non-tumor-bearing mice, RFP-bone marrow cells from tumor-bearing mice and dual color MMT mouse breast cancer cells expressing GFP in the nucleus and RFP in the cytoplasm were co-transplanted in the spleen of nude mice, much more RFP-bone marrow cells were observed in liver metastases formed by the breast cancer cells compared to GFP-bone marrow cells. Thus bone marrow derived from tumor bearing animals appeared to play a role in metastasis formation compared to bone marrow derived from naïve animals. The results suggest that bone marrow and cancer cells mutually affect each other. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 466. doi:10.1158/1538-7445.AM2011-466
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