Abstract 463: Cardiometabolic Risk Factors and Vitamin D 25OH levels in Puerto Rican Adolescents

Abstract

Purpose: Overweight, obesity, hypertension (HTN), insulin resistance, and dyslipidemia have been recognized as cardiometabolic risk factors in adults. Early markers of cardiovascular disease in children are lacking. Low vitamin D (VITD) levels are associated with higher blood pressure, obesity and insulin resistance. We explored the association between traditional cardiometabolic risk factors and VITD levels with HTN status in adolescents. DESIGN METHODS: Cross-sectional pilot study in students from grades 9th - 12th in Puerto Rico. Fasting blood samples to estimate serum lipids, fasting glucose and vitamin D25OH levels were obtained, with anthropometric and blood pressure measurements. Variables described as mean [standard deviation (sd)] or frequencies and percentages as appropriate. Bivariate analysis using chi-square test; statistical significance was set at p<0.05. Results: 78 adolescents, mean age: 16 years were studied. Mean BMI: 23.8 (range 17-39); 19.2% (15/78) were overweight and 16.7% (13/78) were obese. Pre-HTN observed in 7.7% (6/78), with 1 HTN. Hypercholesterolemia (≥170 mg/dl): 16.9% 13/77), low HDL levels (≤ 40 mg/dl): 67.5% 23/77), and hypertriglyceridemia (≥ 110 mg/dl): 15.6% (12/77). VITD levels were low (< 30ng/dL) in 31% 24/77. Obese subjects were more likely to have insufficient VITD levels when compared with the non-obese, (61.5% vs 25%; p=0.02).At least 1 cardiometabolic risk factor was found in 69% (54/78); 33% (26/78) had 2 or more. Conclusion: Obesity is associated with low VITD levels and preHTN. Cardiometabolic risk factors are highly prevalent in our population. Interventions to prevent cardiovascular disease in Puerto Rican adolescents are required.