Abstract
Abstract Lung cancer is the leading cause of cancer deaths worldwide, in both men and women. Estrogen receptors that mediate the biological effects of estrogen and ant-estrogens are very important for the regulation of cell proliferation and differentiation in various human tissues. Recent data suggest that estrogen receptors may affect the initiation and progression of lung cancer. Here we show that estrogen receptor beta (ERβ) is expressed endogenously and it is localized in both cytoplasm and nucleus in the lung cancer cell line A549. Treatment of these cells with 17beta-estradiol does not alter the subcellular distribution of ERβ. Induction in the expression of ERβ in the same cells inhibits cell growth and modulates their resistance to cytotoxic chemotherapy in a ligand-independent manner. These results suggest ERβ as an important player in biology of lung cancer and a potentially useful component in the clinical management of the disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4555. doi:10.1158/1538-7445.AM2011-4555
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