Abstract
Abstract Background We have found that the abundance of peritumoral CD68+ macrophages was associated with patients’ prognosis after curative resection of hepatocellular carcinoma (HCC). However, the role of the pro-tumoral or tumoricidal macrophages is still not clear. Methods In this study, the clinical significance of immunostaining of CD163, a marker of alternatively activated macrophages (M2), in tumor and peritumoral liver tissue from a cohort of 295 Chinese HCC patients who underwent curative resection was evaluated and compared with that of the immunostaining of CD68. The clinical significance of soluble form of CD163 (sCD163) in peripheral blood was also evaluated in another cohort of 107 HCC patients. Results The count of CD163+ cells was well correlated with and much higher than that of CD68+ cells in both tumors and peritumoral liver tissues respectively, which was consistent with the observation from immunostaining by CD68 or CD163 antibody on the consecutive sections. Patients with a higher count of peritumoral CD68+ cells was associated with poor recurrence-free survival and overall survival (P = 0.004 and, P = 0.001, respectively), whereas the counts of tumor and peritumoral CD163+ cells did not. Plasma sCD163 level was associated with active hepatitis-related factors (e.g. serum alanine aminotransferase, serum aspartate aminotransferase, γ-glutamyl transpeptidase and serum alkaline phosphatase). Conclusions CD163+ cell count is of limited significance to predict patients’ prognosis in HCC. Plasma sCD163 was more likely a factor related with active hepatitis rather than tumor related features. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 45. doi:1538-7445.AM2012-45
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