Abstract
Abstract MicroRNA (miR)-155 has been found to be overexpressed in breast cancer cells, but its transcriptional regulation remains elusive. The role of miR-155 is also not determined in breast cancer development and progression. In this study, we identified a FOXP3-BRCA1-miR155 axis in breast cancer cells. MiR-155 is induced by FOXP3 through a transcriptional repression of BRCA1 in breast cancer cells. Likewise, overexpression of miR-155 was found in patients with early stage or triple negative breast cancer, but not in patients with high stage or metastatic breast cancer. Of note, expression of miR-155 in blood cells was higher in patients with localized but not metastatic tumors. In addition, although miR-155 in tumor cells is induced by FOXP3, free or exosomal miR-155 in culture medium was not changed with induction of FOXP3. There is a transcriptional axis of FOXP3-BRCA1-miR-155 in breast cancer cells. MiR-155 is a potential biomarker for early stage breast cancer. Plasma miR-155 appears to be related to that in blood cells but not in tumor cells. Citation Format: Baozhu Yi, Ming Li, Ying Liu, Runhua Liu. FOXP3 transcriptional regulation of MicroRNAs in human breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4429.
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