Abstract
Abstract Changes in metabolism are key contributors to tumorigenesis and metastasis. Micro RNAs (miRNA) play critical roles in glucose and lipid metabolism. In previous studies, miRNA 181a-5p (miR-181a-5p) was shown to be a significant component in down regulation of lung cancer tissue and mesenchymal-like lung cancer cell lines. To define the role of endogenous miR-181a-5p in cancer metabolism, we performed assays for luciferase, Lactate Dehydrogenase (LDH), glucose uptake and mitochondrial ATP synthase inhibitor. It was demonstrated that miR-181a-5p inhibited aerobic glycolysis and lipid metabolism and overexpression decreased LDH and lipid content in lung cancer. Furthermore, the overexpression of miR-181a-5p diminished invasion and migration by inhibition of Sirtuin 1 (SIRT1) and acyl-CoA synthetase long-chain family member 4 (ACSL4). Together these findings suggest that miR-181a-5p might be involved with reprograming lung cancer metabolism. Citation Format: Ji Woong Son, Seul-Gi Kim, In Beom Jeong, Sun Jung Kwon. MicroRNA 181a-5p reprogrammed glucose and lipid metabolism in lung cancer though regulating SIRT1 and ACSL4 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4417.
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