Abstract
Abstract In-vitro studies have demonstrated the ability of BPM31510, a Coenzyme Q10 (CoQ10) containing proprietary formulation to effectuate a metabolic switch from glycolysis to mitochondrial OXPHOS resulting in the activation of apoptotic pathways specifically in cancer cells. The effectiveness of BPM31510 in combination with standard of care chemotherapy agents in in-vitro and in-vivo models has been previously established. The current study was to determine the effect of dose, route of administration and combination with gemcitabine on survival in an animal model of pancreatic cancer. BPM31510 administered in three divided doses (50mg/kg vs 75mg/kg body weight daily, intravenous) was associated with dose dependent increase in survival and was significantly better when combined with gemcitabine. Continuous infusion of BPM31510 significantly improved survival rates compared to three divided doses (50mg/kg or 75mg/kg body weight) of BPM31510, with best outcomes at 200mg/kg body weight dose. Sixty day pretreatment with BPM31510 alone followed by combination with gemcitabine was also associated with improved survival outcomes with either gemcitabine or BPM31510 alone. The data suggests that dose and route of administration of BPM31510 alone or in combination with standard of care chemotherapy agents influences and improves survival in animal model of pancreatic cancer. Citation Format: Niven Narain, Lucia Mauro, Assuan Lens, Viatcheslav Akmaev, Rangaprasad Sarangarajan, Joaquin Jimenez. Effect of pretreatment, dose and route of administration of BPM31510 (Coenyzme Q10 containing proprietary formulation) alone or in combination with gemcitabine improves survival in pancreatic cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4321. doi:10.1158/1538-7445.AM2014-4321
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