Abstract #4317 Peri-operative novel psychological intervention in breast cancer patients aiming to reduce stress responses and improve biomarkers of cancer progression

Abstract

The way the biological system responds to environmental stress depends on the adaptive response and evolution. Each system responds with a molecular model mediated by oxidative stress known as the phenomenon of hormesis. This response, which is summarized in stimulation at low doses and inhibition at high doses of toxic agents, is the key to survival and the acquisition of fitness against environmental stress. Thus the adaptive response to xenobiotics is a product of the molecular signaling that is present from the first bacteria and is part of the endosymbiotic relationship of mitochondria in eukaryotic cells in mitohormesis. In this way, it is possible to deduce that the microbiota plays a role within the holobiont in the transduction of the hormetic response; also, the reactive oxygen species (ROS) induce the exchange of genetic material through the transposable elements (TEs) between the symbionts and the host. It is in this exchange of information that the production of antioxidant secondary metabolites that regulate the oxidative stress induced under hormesis is possible; the epigenetic regulation of biosynthetic gene clusters (BGCs) for obtaining chemically diverse metabolites also occurs. Thus, the search for homeostasis and coevolution within the biological system for the maintenance of metabolic networks is achieved under the cognition provided by hormesis. It is in this way that this evolutionary model becomes a source of new stressors or hormetins, whose mechanism of action is the maintenance of the structural functioning of the system as well as its replication, and thus becomes a new rational strategy for prospecting for new drugs. Thus, the objective of this chapter is to analyze the phenomena of adaptation to environmental stress and its evolutionary role as an innovative model in the discovery of new medicines.