Abstract 4277: TRAF2 is a key mediator of the EGF-induced signaling pathway.

Abstract

Abstract TRAF2 plays a critical role in the mediation of the TNF-R signaling pathway toward activation of NF-κB and JNKs. Here, we reveal a novel function of TRAF2 in the epidermal growth factor (EGF) signaling pathway. Knockdown of TRAF2 blocked EGF-induced AP-1 activity and anchorage-independent cell transformation. We also showed that TRAF2 is required for RSK2 activity through RSK2 ubiquitination and that RSK2 plays a critical role in AP-1 activity mediated through CREB/c-Fos, which regulate anchorage-independent cell transformation. Citation Format: Cong Peng, Feng Zhu, Weihong Wen, Ke Yao, Weiya Ma, Ann Bode, Zigang Dong. TRAF2 is a key mediator of the EGF-induced signaling pathway. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4277. doi:10.1158/1538-7445.AM2013-4277