Abstract
Abstract Alternative splicing of precursor mRNA is a key mechanism of eukaryotic gene regulation. Cancer-associated changes in alternative splicing can modulate gene function or activity, and consequently affect downstream molecular pathways critical for tumorigenesis or metastasis. RNA-Seq has become a powerful technology for genome-wide analysis of alternative splicing. We have developed sensitive and robust computational methods for quantitative analysis of alternative splicing using RNA-Seq data. Using these methods, we have analyzed the alternative splicing profiles of >4000 cancer samples across multiple types of cancer. Our analysis has identified important alternative splicing events that may contribute to the development and progression of cancer. Note: This abstract was not presented at the meeting. Citation Format: Shihao Shen, Ying Nian Wu, Yi Xing. Alternative splicing in cancer transcriptomes. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4277. doi:10.1158/1538-7445.AM2014-4277
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