Abstract 424: Waist Circumference for the Diagnosis of Metabolic Syndrome on Risks of Arterial Stiffness and Diabetes

Abstract

Background: Published studies seldom tested the weight of different waist circumference (WC) cut-off values for the diagnosis of metabolic syndrome (MetS) in predicting clinical outcomes, including cardiovascular disease and diabetes. Methods: This is a Chinese population-based cross-sectional study screening subjects from a Health Examination Program since 1999 to 2015. The MetS identification and scores were determined either according to the Adult Treatment Panel III/ American Heart Association/National Heart, Lung, and Blood Institute (ATP III/AHA/NHLBI)- or Asian-WC cut-off points. The developments of a higher brachial-ankle pulse wave velocity (baPWV) and diabetic-level hyperglycemia were surveyed by comparing the areas under receiver operating characteristic curves (AUC-ROC) for both MetS scores. Results: According to the ATP III/AHA/NHLBI- or Asian-MetS criteria, 6633 (24.8%) or 9133 (34.2%) subjects were diagnosed as the MetS among 26735 study subjects with a mean age of 55 ± 12 years. The stepwise increases in baPWV and prevalence of diabetic-level hyperglycemia were associated with both MetS scores after adjusting for age and sex. The AUC-ROC for the ATP III/AHA/HLBI- vs Asian-MetS scores to predict a higher baPWV (0.685 vs 0.680, p =0.271) and diabetic-level hyperglycemia (0.791 vs 0.784, p =0.546) were similar. Conclusions: In a stepwise manner, both ATP III/AHA/NHLBI- or Asian-MetS scores were strong risk factors for arterial stiffness and diabetes. Through a novel and holistic approach, the predictive performance of the ATP III/AHA/NHLBI-MetS score for the risks of arterial stiffness and diabetes was comparable to the Asian-MetS score among a Chinese population. <!--EndFragment-->