Abstract
Low-level laser therapy (LLLT) has been used as an anti-inflammatory alternative treatment in several disease conditions, even when inflammation is a secondary consequence, such as in myocardial infarction (MI). LLLT treatment effectively reduces MI size and attenuates the systolic dysfunction after MI. However, the mechanism by which LLLT is able to protect the remaining myocardium remains unclear. Here, we tested the hypothesis that LLLT might reduce the hypoxia effects generated by MI. To achieve this purpose, we evaluated, after laser irradiation, the modulation of hypoxia-inducible factor (HIF) and microRNA 210 expressions, which are consistently stimulated under hypoxic conditions. We observed that HIF content presented an up-regulation after MI, however, a significant augmented HIF expression was observed after LLLT. Accordingly, micro-RNA 210 expression in the MI remote area increased even further after laser irradiation. Our data suggest that LLLT stimulates HIF expression pathway, increasing hypoxia-induced microRNA 210 content after MI, therefore, highlighting a possible cardioprotective role of LLLT.
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