Abstract 419: A comparison between the OV100 and Maestro fluorescence imaging systems for noninvasive detection of metastasis.

Abstract

Abstract The OV100 (Olympus Corp.), and Maestro (Perkin-Elmer Inc.), were compared for imaging metastasis in orthotopic lung, liver, pancreas and colon nude mouse tumor models expressing RFP. Non-invasive images of tumor-bearing mice indicated that the Maestro systems outperformed the OV100 for macro imaging. Tumors could be detected earlier with the Maestro system than with the OV100. By separating skin and food autofluorescence, the Maestro provides a high-contrast image. The Maestro can produce a composite image of five unmixed components and detects tumors deeper than the OV100. The Maestro can also detect more color signals simultaneously. However, the OV100 has higher resolution and even a single cell can be imaged, for example via a skin-flap. The results of this study suggest that the two instruments are complimentary. Citation Format: Yong Zhang, Nan Zhang, Robert M. Hoffman, Ming Zhao. A comparison between the OV100 and Maestro fluorescence imaging systems for noninvasive detection of metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 419. doi:10.1158/1538-7445.AM2013-419