Abstract 4185: Serum concentrations of angiogenesis-related molecules in patients with pancreatic cancer

Abstract

Abstract Objectives: A number of antiangiogenic inhibitors have been studied in clinical settings, some of which are now under clinical evaluation in pancreas cancers (PC), therefore, prognostic marker of angiogenesis-related molecules in PC is needed. The aim of this study is to evaluate the serum levels of angiogenesis-related factors in patients with pancreas cancer. Methods: The plasma samples obtained from 45 pancreas cancers (PC) were analyzed compared with 9 pancreatitis (P), 16 benign hepatobiliary diseases (HD) and 58 colorectal cancers (CC). Serum angiogenesis-related factors including Angiopoietin-2, Follistatin, G-CSF, HGF, IL-8, Leptin, PDGF-BB, PECAM-1 and VEGF were determined by antibody suspension bead arrays system. Results: All of the serum angiogenesis-related factors were not increased in PC compared with P and HD, while those of CC were markedly increased. Although IL-8 levels were not increased in most samples of PC, it was significantly increased in patients with distant metastases and there was a trend toward to a shorter survival. Conclusions: Serum levels of angiogenesis-related factors were basically not increased in patients with PC, however, serum IL-8 levels may reflect PC progression and shorter survival. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4185. doi:10.1158/1538-7445.AM2011-4185