Abstract 4165: Unstable microsatellite instability proportion among unselected ovarian and endometrial cancer patients among Korean population

Abstract

Abstract Background: There are several availability of microsatellite instability(MSI) among ovarian and endometrial cancer for detection of Lynch syndrome and biomarker of immune chemotherapeutic treatment. We investigated to know proportion of abnormal microsatellite instability (MSI-L/H). Methods: Through retrospective search,we identified 51 cases of MSI samples from ovary and endometrial cancer visiting hereditary gynecologic cancer center. Results: We found 34 ovary cancer, 13 endometrial cancer and 4 colon cancer patients. Median age was 56.6(18~78). About thirty percent have family cancer history among patient relatives (14/45(31.1%)). Early stage cancer (I~II) (4/25,16.0%) have higher incidence than late stage cancer (III~IV) (2/28,7.1%). Abnormal MSI have three serous type and endometrioid type pathology. Among abnormal MSI, we found two MSI-L and four MSI-H (6/51(11.8%)). We found one MSI-H ovary cancer,3 MSI-H endometrial cancer patients (1/34(2.9%),3/13(23.1%)). Conclusions: There are about 10 percent of abnormal MSI in this study group Citation Format: Min Kyu Kim. Unstable microsatellite instability proportion among unselected ovarian and endometrial cancer patients among Korean population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4165.