Abstract 4155: Genome-wide association study of survival in early stage non-small cell lung cancer

Abstract

Abstract Lung cancer, especially non-small cell lung cancer (NSCLC), is the leading cause of cancer-related deaths all over the world. Studies have indicated that molecular biomarkers including genetic variants may provide additional values for the targeted treatments and clinical outcomes of NSCLC patients. In this study, we evaluated the associations between genome-wide genetic variants and the survival of NSCLC in a cohort of 365 early-stage NSCLC patients with surgery, and replicated sixteen promising loci in another independent cohort with 327 early-stage NSCLC patients in Chinese population. The results showed that rs10023113 in CAMK2D was consistently associated with survival of early-stage NSCLC in the GWAS scan and the replication cohort [GWAS scan: hazard ratio (HR) = 2.84; 95% confidence interval (CI) = 1.90-4.23, P = 1.29×10-6; replication cohort: HR = 2.19, 95% CI = 1.15-4.21, P = 1.80×10-2]. When combining all the patients, the results showed that the variant allele of rs10023113 was significantly associated with poor prognosis of NSCLC with P value reaching 3.40×10-7 (HR = 2.30, 95% CI = 1.67-3.17). These findings suggest that CAMK2D rs10023113 may be a potentially prognostic marker for overall survival of early-stage NSCLC patients in Chinese population. Citation Format: Hongxia Ma, Guangfu Jin, Zhibin Hu, Hongbing Shen. Genome-wide association study of survival in early stage non-small cell lung cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4155. doi:10.1158/1538-7445.AM2014-4155