Abstract 41: Functional Outcome Of Patients 85 Years Or Older With Acute Ischemic Stroke Following Endovascular Treatment - A Substudy Of The Hermes Meta-analysis

Abstract

Introduction: Previous studies have reported poor outcomes and high rates of mortality following endovascular therapy (EVT) for ischemic stroke in older patients. However, patients ≥85 years were underrepresented in most randomized trials. Our aim was to study the influence of age on outcome and EVT effect for ischemic stroke in patients aged ≥85 years. Methods: Data were from the HERMES collaboration, a meta-analysis of 7 randomized trials that tested the efficacy of EVT. Two multivariable ordinal logistic regression were used to compare the association between EVT and 90-day functional outcome (modified Rankin Scale, primary outcome) in patients ≥85 years old to those who were younger. Secondary outcomes included mortality at 90 days and symptomatic intracranial hemorrhage (sICH) at 24 hours. Results: We included 1764 patients in the analysis, of whom 77 (4.4%) were ≥85 years old. While patients ≥85 years had worse outcomes (adjusted odds ratio [aOR] 0.26 (95%CI:0.14-0.48) and higher mortality rates (aOR:3.28, 95%CI:1.54-6.97) compared to those <85 years, a significant benefit of EVT was observed in the ≥85-year-old patient subgroup (common OR:4.20 (95%CI:1.56-11.32, Figure). Patients ≥85 years undergoing EVT had lower rates of mortality than those in the control group (31% vs. 54%, p<0.01). Age ≥85 years was not significantly associated with higher rates of sICH (adjusted cOR:2.3, 95%CI:0.59-8.93). Conclusion: Patients ≥85 years old with independent premorbid function more often achieve good functional outcomes when treated with EVT compared to conservative management, with lower rates of mortality and no differences in sICH rates. EVT should therefore not be withheld in this subgroup.