Abstract
Abstract MicroRNAs (miRs) are small 20-24 nucleotide non-coding RNA molecules that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both stability and translation of mRNAs. The expression and activity of miRs vary in specific cell types and disease states. Several groups have investigated and determined the strong association between specific expression patterns of miRs and various stages of prostate cancer. Recent findings have highlighted the strong correlation between overexpression of miRs (21, 210, 125b, 221 and 222) and cancer development and progression. In this study we determined whether modulation of miR expression using a natural compound suppresses PCa growth. Previously we published that psoralidin inhibits prostate tumor growth and progression in both in vitro and in vivo models. While studying the expression patterns of a panel of miRs in control and psoralidin treated prostate cancer cells we found that psoralidin significantly inhibits expression of two specific miRNAs, miR-21 and miR-210 in turn resulting in the inhibition of EGFR-, MAPK- and PI3K-mediated prosurvival signaling and induction of JNK-mediated apoptosis in prostate cancer cells. Currently, we are overexpressing and inhibiting these two miRs to determine whether it modulates psoralidin-mediated effects on prostate cancer cells. The outcome of our study may provide encouraging data that may enable us to exploit miRs as therapeutic targets for the treatment of various malignancies. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4043.
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