Abstract
Abstract Supported by: National Natural Science Foundation of China, No.81172282; National Natural Youth Science Foundation of China, No.81302151; Shenzhen Peacock Plan, No.KQCX20130621101141669; Planned Science and Technology Project of Shenzhen, No.GJHS20120621142654087; the Key Laboratory Project of Shenzhen, No.ZDSY20130329101130496; Technological innovation group of SZU grants, No.T201202; NIH grants DK087454, CA146799, CA173390; an American Cancer Society Clinical Research Professorship. Gastric cancer (GC) remains a major health threat worldwide, and is one of the leading causes of cancer-related deaths in China. The discovery of microRNAs (miRNAs) has provided a new and powerful tool for studying diagnostic biomarkers and effective therapeutic targets in GC. By using microarray analyses of benign and malignant gastric epithelial cell lines (HFE145, NCI-N87, MKN28, RF1, KATO III and RF48), we discovered dysregulated 16 miRNAs, of which 11 were validated by real-time qRT-PCR. Based on miRWalk online database scans, 2532 potential mRNA targets of these 16 miRNAs were identified. Bioinformatic analyses suggested that these predicted targets were principally involved in tumor pathogenesis, MAPK signaling, and apoptosis. Finally, miRNA-gene network analyses identified miRNA- 125b as being potentially vitally important in GC. Citation Format: Xiaojing Zhang, Xianling Feng, Yin Peng, Mengting Yang, Yong Huang, Xinmin Fan, Stephen J. Meltzer, Zhe Jin. Integrated analysis of miRNA profiling and bioinformatics reveals the potential key miRNAs in gastric cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3996. doi:10.1158/1538-7445.AM2015-3996
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