ABSTRACT 398

Abstract

Background and aims: Different respiratory support in preterm infants is applied. Aims: To realize the value of effects of two different models of respiratory support (invasive mechanic ventilation/surfactant therapy and non invasive mechanic ventilation/nCPAP) on evolution of necrotizing enterocolitis in very low birth premature neonates that were diagnosed as RDS. Methods: The neonates between January 2009 and June 2012, with the gestation weeks of 24–32 week and were divided into two groups according to the kind of mechanic ventilation. Infants were randomly assigned to intubation and surfactant treatment (within 1 hour after birth) or to nCPAP treatment initiated in the delivery room. In both two groups evolution of ≥ grade 2 NEC, duration of parenteral nutrition (PN) and the onset time of enteral nutrition were compared. Study approved by a local ethics committee. Results: 80 neonates given invasive mechanic ventilation support and 113 neonates given nCPAP support were included in the study. NEC was developed in 8 cases (%10) of first group and 9 cases (%8) of second group. The duration of PN therapy in invasive mechanic ventilation and nCPAP were found 15,4 ± 9 and 12,1 ± 9,5 days respectively. The attainment of full enteral nutrition in invasive mechanic ventilation and nCPAP was found 19,0 ± 9,5 and 15,1 ± 9,5 days respectively. In invasive MV group, both PN duration and onset time of full enteral nutrition were found significantly longer then the nCPAP (p=0,017), (p=0,006). Conclusions: nCPAP support had no adverse effect on evolution of NEC in premature neonates. In nCPAP group, duration of PN therapy and attainment of full enteral nutrition were found shorter.