Abstract 3878: Bach1 promotes liver metastasis of colorectal cancer cells by regulating c-Myc and SOX4.

Abstract

Abstract Bach1 is a basic leucine zipper transcription factor that binds to Maf recognition elements (MAREs) and has recently been identified as the regulator of breast cancer metastasis. Bach1 promotes breast cancer metastasis to bone by directly upregulating MMP1 and CXCR4 and it is critical for the cell transformation and tumor growth induced by activated H-RasV12. Here, we demonstrate the oncogenic mechanisms of Bach1 in colorectal cancer. Ectopic expression of Bach1 increases invasion of colorectal cancer cells, whereas knockdown of Bach1 significantly reduces the invasive efficiency of the cancer cells. In a mouse model, suppression of Bach1 expression significantly inhibits intravasation and liver metastasis of colorectal cancer cells. The mechanism involves upregulation of c-Myc and SOX4 expression by Bach1 maintaining ERK signaling. Finally, we confirmed the expression of Bach1 is high in the patient samples of colorectal cancer and metastasis, unlike normal colon tissues. These results suggest Bach1 as a novel target for cancer therapeutic strategy. Citation Format: Jieun Yun, Yeong Nang Jo, Song-Kyu Park, Jin-Ah Kim, Junguk Yang, Chang Woo Lee, Won Kee Yoon, Ok-Jun Lee, Sang-Bae Han, Robert C. Doebele, Jong Soon Kang. Bach1 promotes liver metastasis of colorectal cancer cells by regulating c-Myc and SOX4. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3878. doi:10.1158/1538-7445.AM2013-3878