Abstract
Abstract Background: Hispanics are the largest non-white ethnic group in the U.S. and account for approximately 17% of U.S. population. Hispanics have higher incidence and mortality rates for gastric cancer than whites or Asians. Association studies have identified several genetic susceptibility loci and intermediate phenotypic biomarkers for gastric cancer in whites and Asians. However, no studies have evaluated genetic susceptibility and intermediate phenotypic biomarkers in Hispanics. Methods: In a case-control study of 132 Hispanic gastric cancer patients and 125 Hispanic controls, we evaluated the association of 5 previously identified, single nucleotide polymorphisms (SNPs) predisposing to gastric cancer in whites and/or Asians. In addition, two intermediate phenotypic markers in peripheral blood leukocytes, i.e., telomere length and mitochondrial DNA (mtDNA) copy number, were examined with respect to risk for gastric cancer. Results: The variant C allele of the SNP rs2294008 in PSCA gene was associated with a significantly reduced risk of gastric cancer (per allele OR=0.60, 95%CI, 0.41-0.88; P=0.009) after adjusting for age, gender, and smoking status. Low mtDNA copy number was associated with a significantly increased risk of gastric cancer (OR=6.83; 95%CI, 3.33-14.00; P <0.01). Telomere length was not significantly associated with the risk of gastric cancer (OR=1.25, 95% CI, 0.70-2.24; P=0.450). Conclusion: Hispanics share certain genetic susceptibility loci and intermediate phenotypic biomarkers with whites and Asians, but may also have distinct genetic susceptibility factors related to risk for gastric cancer Citation Format: Yuhui Sun, John Stroehlein, Jaffer Ajani, David Chang, Xifeng Wu, Jian Gu. Genetic and intermediate phenotypic susceptibility markers of gastric cancer in Hispanic-Americans: A case control study. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3850. doi:10.1158/1538-7445.AM2014-3850
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