Abstract 3801: Spatially resolved laser-activated cell sorting (SLACS) for high throughput spatial cell sorting in tumor research

Abstract

Abstract Understanding of tumor heterogeneity and the microenvironment is a cornerstone in advancing cancer research and therapy. The Spatially resolved Laser-Activated Cell Sorter (SLACS) represents a novel approach in cancer research, allowing for high-throughput, precise cell isolation while preserving spatial information, which is crucial for studying tumor heterogeneity and the tumor microenvironment. The SLACS instrument utilizes laser-activated technology for selective isolation of cells from heterogeneous tissue samples, optimized for accuracy, speed, and minimal cell damage. This instrument has demonstrated effective isolation of specific cell types from complex tissue matrices, maintaining cell integrity and spatial information. Its high-throughput capacity significantly reduces sample processing time. This groundbreaking tool offers detailed exploration of tumor heterogeneity and the tumor microenvironment, providing valuable insights into cancer biology and potential therapeutic targets. Citation Format: Sumin Lee, Amos Chungwon Lee. Spatially resolved laser-activated cell sorting (SLACS) for high throughput spatial cell sorting in tumor research [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3801.