Abstract
Background: We aimed to compare the clinical features and short-term outcomes of hemorrhagic stroke (HS) to ischemic stroke (IS) in atrial fibrillation (AF) patients using a large contemporary cohort. Methods: The Neuro-AFib study is a multicenter effort to elucidate the current causes and consequences of IS and HS in AF patients. The retrospective phase of the study is underway, aimed at obtaining detailed clinical, laboratory and multimodal neuro- and cardiac imaging data from ~9,000 patients with AF admitted to 30 academic stroke centers in the US with an IS or HS between 1/2018-12/2019. Preliminary clinical data from 12 sites are presented in this abstract. Results: Of 4764 stroke admissions with AF, 820 (17.2%) had HS and 3944 IS. Patients with HS were younger (74.8 + 12 vs 76.8 + 12), more likely to be male (54% vs 46%) and had lower CHA 2 DS 2 -VASC (3.6 + 1.6 vs 3.9 + 1.6) than IS [all p<0.05]. Patients with HS were more likely to be on AC compared to IS (60% vs 38%, p<0.001). Within the HS cohort, 32% were on direct oral anticoagulant, 28% on warfarin, 16% on antiplatelet, and 24% on no antithrombotic. Patients with HS had worse outcomes than IS in terms of in hospital case fatality (32.4 vs 10.3%, p<0.001) and severe disability (modified Rankin Scale 4-5) at discharge (63.3% vs 53.7%, p=0.002) despite similar rates of severe disability before admission (7% vs 6.2%, p=0.73). All of the reported associations remained significant after adjustment for age, sex and other relevant covariates. Conclusions: Preliminary findings from the Neuro-AFib study show significantly worse outcomes for HS compared to IS in AF patients, with triple case fatality and elevated severe disability risks. These results showcase the importance of identifying AF patients at high HS risk. Detailed imaging markers of HS risk including microbleeds, superficial siderosis, leukoaraiosis within the full cohort will be analyzed and discussed during ISC 2021.
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