Abstract 3797: Efficacy and pharmacokinetics of gold nanorods coupled with laser-induced photoplasmonic therapy in solid tumor bearing mice

Abstract

Abstract Gold nanorods (GNR) are characterized by absorbing near IR beams and emitting heat which is called photoplasmonic response. Yet, the efficacy of nanoparticles is limited due to intratumoral tissue distribution reasons. In addition, distribution of GNRs to normal tissue might result in non specific toxicity. In the current study, we assessed the intratumoral and tissue distribution of PEGylated GNRs as well as its antitumor efficacy (coupled with laser photoplasmonic sessions) when given intravenously or intratumoral to solid tumor bearing mice. PEGylated GNRs with a longitudinal size of less than 100 nm were prepared with aspect ratio of 4.6 and showed strong surface plasmon absorption at wave length 800 nm. Pharmacokinetics of GNR after single I.V. administration (0.1 mg/kg) showed very short systemic circulating time (less than 3 h). On the other hand, tissue distribution of I.V. GNR (0.1 mg/kg) to normal animals showed preferential deposition in spleen tissue. Repeated administration of I.V. GNR resulted in preferential accumulation in both liver and spleen tissues. In addition, I.V. administration of GNR to Ehrlich carcinoma tumor bearing mice resulted in similar tissue distribution; tumor accumulation and anti-tumor effect compared to intratumoral administration. In conclusion, the concentration of GNR achieved within tumors microregions after I.V. administration was comparable to I.T. administration and sufficient to elicit tumoral growth arrest when coupled with laser-aided photoplasmonic treatment. Citation Format: Ahmed M. Al-Abd, Ali A. Shabaka, Osama A. El-Shabrawy, Nemat A. Yassin, Sawsan S. Mahmoud, Siham M. El-Shenawy, Emad Al-Ashqar, Wael H. Eisa, Niveen M. Farag, Marwa A. El-Shaer, Nabila Salah, Mostafa A. El-Sayed. Efficacy and pharmacokinetics of gold nanorods coupled with laser-induced photoplasmonic therapy in solid tumor bearing mice. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3797. doi:10.1158/1538-7445.AM2014-3797