Abstract 365: Adiponectin has Greater Association with Left Ventricular Mass Index and Coronary Artery Calcification Score in Lean Compared to Overweight-Obese Subjects: The CARDIA Study

Abstract

Objective: To compare the association of adiponectin with left ventricular mass index (LVMi) and coronary artery calcification (CAC) score in lean and overweight-obese subjects. Methods: The CARDIA (Coronary Artery Risk Development in Young Adults) study enrolled black and white adults aged 18 to 30 years in 1985 to 1986. Adiponectin was measured 15 years after baseline. At Years-20 and -25, subjects underwent CT-derived CAC score measurement and M-mode echocardiography, respectively. BMI at Year-15 was categorized into 3 groups (below <25, 25-30, ≥30). Adiponectin and CAC score were log-transformed. Effect modification by BMI for association of adiponectin with LVMi and CAC score was assessed using stratified multivariable linear regression analysis adjusted for demographics and traditional cardiovascular risk factors. Results: Mean age of the 2121 included participants was 50.2±3.6 years and 58.7% were females. Adiponectin level was positively associated with LVMi and CAC score (table). In stratified analysis, positive association of adiponectin with LVMi was observed in subjects with BMI <25 (β=3.1, p=0.005) but not in those with BMI of 25-30 (β=-1.5, p=0.14) or ≥30 (β=-0.23, p=0.8). Adiponectin also showed strong association with CAC score in subjects with BMI<25 (β=0.3, p=0.03) and not in those with BMI of 25-30 (β=0.03, p=0.8) or ≥30 (β=0.18, p=0.28). Conclusion: Adiponectin at Year 15 has pronounced association with LVMi measured 10-years later and CAC score measured 5 years later in lean subjects but not in overweight-obese subjects. Higher adiponectin levels in young-middle aged adults are associated with subclinical cardiovascular disease later in life.