Abstract 3619: Severity of prostate cancer and socioeconomic status in Hispanics in Puerto Rico.

Abstract

Abstract In Puerto Rico, prostate cancer age adjusted death rate between 2004-2008, was 30.1 per 100,000 males per year, higher than for Hispanics (21.2) and white non Hispanics (26.4) in the United States. Increased mortality could be due to differences in disease biology, exposures or socioeconomic factors. Recognizing these factors our group is involved in studying the relationship of Ancestry Informative Markers (AIMs) and Single Nucleotide Polymorphisms(SNPs) with risk/aggressiveness of prostate cancer in African American and Puerto Rican cohorts of patients that underwent a radical prostatectomy. In addition to the genetic and AIMs analysis, we have assessed the statistical association between prostate cancer severity and socioeconomic status controlling for potential confounders. Here we report the results in a group of 244 participants in Puerto Rico. The statistical method of principal component analysis (PCA) was used to determine the socioeconomic status (SES) at the geographical area of group level. We used the following four socioeconomic indicators available in the US Census 2000: unemployment rate, the inverse of median annual household income, percentage of the population living below the poverty level, and percentage of the population aged 25 years or older with less than 12 years of education. Due the fact that the first principal component (PC) has the cumulative variance greater than 75%, we selected this PC to define the socioeconomic profile (SEP) index at the group level as a proxy of the SES. We categorized the SEP using quintiles to set the scale boundaries, where SEP1 represents the highest socioeconomic level (lowest social deprivation) and the SEP5 represents the lowest socioeconomic level (highest social deprivation). Definition of disease risk groups was :a) Low risk: pT2 and Gleason score less than or equal to 3+4=7; b) High risk: pT3, or positive surgical margin, or Gleason score greater than or equal to 4+3=7.Results: The odds(OR) of being diagnosed with Gleason scores > 7 is 1.75(95%CI)in SEP5 than in SEP1. A gradient in the odds ratios is observed as the SEP decreases. The odds of being categorized as “high risk disease” among participants in SEP5 was 45% higher (OR: 1.45, 95% CI: 0.60-3.52) the odds of being categorized as “high risk disease” among participants in SEP1. This increase was not statistically significant (p>0.05). Detailed analyses will be presented. Conclusions: Further analyses are needed with an expanded number of participants to assess prevalence of high severity of disease in the SEP5. Citation Format: Margarita Irizarry Ramirez, Jeannette Salgado, Marievelisse Soto, Curtis Pettaway, Erick Suarez, Mario Quintero, Lourdes Guerrios, Ricardo Sanchez-Ortiz. Severity of prostate cancer and socioeconomic status in Hispanics in Puerto Rico. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3619. doi:10.1158/1538-7445.AM2013-3619