Abstract 3572: SNPs in lncRNA genes are associated with non small cell lung cancer in a Chinese population

Abstract

Abstract Background: Recent genetic studies indicate that single nucleotide polymorphisms (SNPs) in the genes encoding non-coding RNAs are associated with lung cancer susceptibility. But the comprehensive analysis of SNPs in long non-coding RNA (lncRNA) genes has not been elucidated. Methods: Based on the previous expression microarray of lncRNAs, we genotyped 17 SNPs located in 13 selected lncRNA genes by the TaqMan method in 1294 non-small cell lung cancer (NSCLC) cases and 1729 controls. Then we followed up NSCLC patients to get the survival data, and conduct logistic regression, Kaplan-Meier method and Cox hazards regression analysis to explore the associations of SNPs with NSCLC risk and overall survival (OS). Results: We identified 4 SNPs significantly associated with NSCLC risk. For rs498238, compared with CC genotype, TT genotype could decrease the risk of NSCLC (adjusted OR=0.32, 95%CI=0.11-0.92, p=0.034). As for rs16901995, TT genotype showed significantly protective effect compared with CC genotype (adjusted OR=0.76, 95%CI=0.59-0.99, p=0.040). For rs219741 dominant model, increased risk of NSCLC was evident in younger patients (age <60) compared those with wild type (adjusted OR=1.47, 95%CI=1.03-2.10, p=0.033). Rs3113503 demonstrated a controversial effect on NSCLC risk. No SNPs showed effects on overall survival of NSCL patients. Conclusion: Our findings indicated that genetic variants within lncRNA genes may predict NSCLC risk in Chinese population. Citation Format: Ruoyang Wang, Biyun Qian. SNPs in lncRNA genes are associated with non small cell lung cancer in a Chinese population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3572.