Abstract 3553: OralDB, A integrative data portal for oral and oropharyngeal cancer omics and clinical research

Abstract

Abstract Oral and oropharyngeal cancer is one of the more common cancers worldwide, with a poor prognosis in advanced stages and a higher incidence in Asian populations than in other regions. Its affected Affected areas include the lips, gums, tongue, the inside of the cheeks, the roof of the mouth, the floor of the mouth, the tonsils, and the oropharynx. Currently, the distribution of RNA expression data and clinical data in oral and oropharyngeal cancer is fragmented, impeding effective data mining for the discovery of novel biological markers and testing of new hypotheses. We constructed an oral and oropharyngeal cancer-specific database with expression dataRNA expression and clinical data from more than 4,356 patients in 41 studies. The RNA Expression data from 23 genome-wide platforms are carefully processed and quality-controlled, while clinical data is standardized and tightly managed. With the support of this oral and oropharyngeal cancer-specific database oral cancer-specific database, we have created an open-access web resource, the Oral and Oropharyngeal Cancer Browser, to facilitate researchers interested in oral and Oropharyngeal cancer to quickly access and analyze all currently published RNAoral cancer expression data and clinical data. Users can perform a meta-analysis of Oral and oropharyngeal oropharyngeal cancer to quickly understand the results of tumor versus non-malignant tissue (normal), differential gene expression, and expression-survival associations. Flexible options for survival analysis, comparative analysis, and correlation analysis based on a single dataset are also available. At the same time, the database also accepts the user's own input data and allows the user to do theircarry out their own analysis by combining the input data with the existing data in the database. Citation Format: Junlin Wang, Pui Ying Lam, Yuxiong Su, Junwen Wang. OralDB, A integrative data portal for oral and oropharyngeal cancer omics and clinical research [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3553.