Abstract 3448: ERG-negative index tumor status combined with obesity predict prostate cancer progression in Caucasian American prostate cancer patients

Abstract

Abstract Introduction: and Objectives: A significantly lower prevalence of ERG oncoprotein has been reported for African American (AA) compared to Caucasian American (CA) prostate cancer (PCa) patients. This difference has been observed when examining prostate cancer (PCa) index tumors as well as for comparisons of non-index tumor foci. To evaluate the potential of ERG status in predicting disease progression, this study examined a large cohort of AA and CA PCa patients within a racially diverse, equal access, military health care center. Methods: Representative sections of whole mounted prostatectomy specimens from AA (n = 373) and CA (n = 684) patients were evaluated for ERG oncoprotein status by immunohistochemistry. Demographic, clinical, and pathologic patient features, including body mass index, were compared across ERG status (positive vs. negative). Time to event regression analysis was used to model ERG status as a putative predictor of biochemical recurrence (BCR) and distant metastasis. Results: A significantly lower prevalence of ERG positivity was noted in both index and non-index tumors of AA patients as compared to CA patients. Among CA patients only, ERG-negative index tumors were associated with greater odds of developing BCR and metastasis. Similarly, among CA patients only, having an ERG negative index tumor and being obese at time of prostatectomy was strongly associated with developing biochemical recurrence and metastasis. Conclusions: These provocative data warrant further investigation of the combined roles between race, obesity, and ERG status on PCa progression. Despite a robust sample size of AA men, the absence of statistically significant associations between ERG and obesity status on disease progression among AA patients could be attributed to insufficient statistical power. Source of Funding: This research was supported by the National Cancer Institute R01CA162383 grant to SS, by the Center for Prostate Disease Research and by the EDRN/NCI ACN12011-001 to GP, AD, IAS, DGM and SS. Citation Format: Jennifer Cullen, Denise Young, Yongmei Chen, Michael S. Degon, Wagner Baptiste, James S. Farrell, Jason S. Sedarsky, Huai-Ching Kuo, Jacob Kagan, Sudhir Srivastava, Inger L. Rosner, Gyorgy Petrovics, Albert Dobi, David G. McLeod, Shiv Srivastava, Isabell A. Sesterhenn. ERG-negative index tumor status combined with obesity predict prostate cancer progression in Caucasian American prostate cancer patients. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3448.