Abstract 342: Initial Serum Uric Acid and Post Cardiac Arrest Patient Outcomes with Respect to Cardiogenic Causes of Arrest

Abstract

Objective: Post cardiac arrest patients experience neurologic and systemic ischemic-reperfusion injury. Uric acid (UA) can be a marker of oxidative stress and severity of various cardiogenic diseases, but also has antioxidant capacity with neuroprotective effects. We aimed to evaluate the association between initial UA and neurologic outcomes of survivors of non-cardiogenic and cardiogenic causes of cardiac arrest. Methods: This was a retrospective observational study of out of hospital post cardiac arrest patients who had initial UA at admission. Association between UA and cardiogenic cause of arrest was analyzed by linear regression. Then neurologic outcome and UA was assessed with multivariate logistic regression analysis by cardiogenic and non-cardiogenic cause of arrest. Results: A total of 126 patients were analyzed. UA was significantly lower in the poor neurologic outcome group than in the good neurologic outcome group [7.9 (1.6) vs. 7.0 (1.8), P<0.01]. Cardiogenic cause of arrest was significantly associated with UA levels [β coefficient 0.87 (0.26-1.49), P=0.01]. In the logistic regression of neurologic outcome and UA by cardiogenic cause of arrest, poor neurologic outcome was not associated with UA in cardiogenic causes of arrest [OR 0.91 (0.62-1.33) P=0.62], but was associated with UA in non-cardiogenic causes of arrest [OR 0.47 (0.23-0.97), P=0.04]. Conclusion: With respect to neurologic outcome by cardiogenic cause of arrest, lower uric acid was associated with poor neurologic outcomes in non-cardiogenic causes of arrest.