Abstract 3368: Association of Superoxide Dismutase polymorphism and severity of Brain Infarction

Abstract

Objective. Determine the relationship between Cu-Zn and Mn Superoxide Dismutase (SOD) polymorphism with the clinical presentation and outcome after acute brain infarct. Background. The SOD polymorphism has been linked with mechanisms of damage in Stroke. There are no clinical studies that demonstrate their influences in the severity or prognosis of acute cerebral infarction. Methods. Of 195 patients admitted prospectively with stroke in the Department of Neurology, University Hospital “Dr. José Eleuterio González” UANL from June 2008 to July 2010. We included 140 patients with acute brain infarct and 140 healthy controls. We analyzed polymorphisms of superoxide dismutase (Mn CuZn) and compared it with demographic, clinical and neuroimaging studies. We used Chi-square, U-Mann Whiney test and Cox logistic regression adjusted for age, gender and etiology. Results. We included 85 (61%) men and 55 (39%) women, mean age 63 ± 1.4 (31-94) years. The most common etiology was atherosclerotic (41%) and small vessels disease (17%). The prevalence of Mn CuZn polymorphism did not differ between healthy subjects and patients with stroke, but the presence of the Ala allele of MnSOD was associated with the occurrence of severe stroke (p=0.016) and a worse functional outcome at hospital discharge (p=0.076). Conclusions. SOD polymorphisms are not associated with the occurrence of stroke, but may influence the severity of their clinical presentation.