Abstract
Abstract Ezrin is a cytoskeleton protein actively involved in regulating the growth and metastatic capacity of cancer cells. It has recently been reported to be to be associated with poor prognosis high grade soft tissue sarcoma (STS) and to mediate growth and survival through AKT pathway. To further validate the prognostic value of ezrin in STS, we evaluated 229 extremity primary STS using tissue microarrays and immunohistochemistry. Ezrin expression was correlated with metastasis during follow-up for at least 5 years or until death.185 of the 229 cases analyzed (80%) showed ezrin immunoreactivity in the membrane and cytoplasm of the tumor cells. Multivariate analysis with other known risk factors, including size, vascular invasion and necrosis showed that ezrin expression was significantly associated with development of distant metastasis during follow-up (P = 0.01, 95%CI 1.4-3.4). Ezrin expression was also correlated with AKT pathway changes, evaluated by gene expression. Our findings suggest that ezrin is a promissing prognostic marker in highly malignant STS and support an interaction between ezrin and AKT in the genesis of STS metastasis. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3310.
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