Abstract
Abstract Esophageal cancer (ESC) is an aggressive disease with a poor overall prognosis. Survival rate of patients with cStage II/III ESC who underwerrt surgical resection have been improved, whereas half of these patients frequently caused recurrences. It has been thought that the lymph node metastasis was deeply related to the relapse of ESC. However, clinical signification of micrometastases in lymph nodes remain unclear because of complexity in the procedure to detect micrometastasis. Here we report that the impact of micrometastasis in lymph nodes on the recurrence of ESC. The aim of this study was to confirm the relation between noccult nodal metastasis and recurrence of in resected cStage II/III ESC. A total of 98 patients with ESC resected at Osaka City University hospital between January 2000 and January 2007 were targeted. Micrometastasis was investigated with one-level cytokeratin immunohistochemistry(IHC)and routine histological assessment by hematoxylin-eosin sections. Judgment of micrometastasis was done with discovery of cluster cells. Uni-and multivariate analyses of the independent recurrect facters were performed using the Cox proportional hazards regression model. A total of 6,172 lymph nodes(average 63) were examined from 98 patient, also 140 lymph nodes of micrometastasis(average 1.4) were detected. The micrometastasis was not possible to detect with routine histological assessment by hematoxylin-eosin sections. A clear difference of detected micrometastasis between relapse patients(45 patients,83%) and no relapse patient(15patients,34%) was admitted. In univariate analyses, curability(p=0.000),v facter(p=0.046),pN facter(p=0.026),pM facter(p=0.016),pStage(p=0.002),total metastatic lymph node count(p=0.000),total metastatic lymph node count added micrometastasis(p=0.000) were recurrence facters. In multivariate analyses, total metastatic lymph node count added micrometastasis were independent recurrence facters(Hazard ration 13.059,p=0.000) finally. Therefore, the number of total metastatic lymph nodes with micrometastasis have pivotal impact on the recurrence of ESC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3294.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
